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  1. General Info
  2. Effects Info
  3. Reference
Drug Interaction Details
01. General Information
Pair Name Lupeol, Sorafenib
Phytochemical Name Lupeol (PubChem CID: 259846 )
Anticancer drug Name Sorafenib (PubChem CID: 216239 )
Structure of
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2D MOL 3D MOL
Structure of
Anticancer Drug		 2D-img
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2D MOL 3D MOL
02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Decreasing Drug Toxicity
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The theory of cold and heat
Drug Name Sorafenib
Adverse Reactions Facial red macules, dry skin, acne, alveolitis. This was inferred hot nature anticancer drug.
Recommendations Cold: Ilex hainanensis; Mangifera indica; Camellia sinensis; Sophora flavescens; Eriobotrya japonica; Citrus aurantium;
Reference Malignant tumors in the era of immunotherapy based on traditional Chinese medicine's "cold and hot theory" Construction of integrated traditional Chinese and Western medicine treatment paradigm[J]. Modern Journal of Integrated Traditional Chinese and Western Medicine,2023,32(12):1712-1716. DOI:10.3969/j.issn.1008-8849.2023.12.022.　　ref_link
Combination Pair ID: 223
Ref_1
Pair Name Lupeol, Sorafenib
Disease Info [ICD-11: 2C12] Hepatocellular carcinoma Investigative
Biological Phenomena Induction-->DNA damage
Gene Regulation Up-regulation Expression FAM20C hsa56975
Up-regulation Expression ROS1 hsa6098
Down-regulation Expression TP53 hsa7157
In Vitro Model Huh-7 Adult hepatocellular carcinoma Homo sapiens (Human) CVCL_0336
Result Implication of Lupeol in compensating Sorafenib-induced perturbations of redox homeostasis: A preclinical study in mouse model
03. Reference
No. Title Href
1 Implication of Lupeol in compensating Sorafenib-induced perturbations of redox homeostasis: A preclinical study in mouse model. Life Sci. 2023 Jun 1;322:121647. doi: 10.1016/j.lfs.2023.121647. Click
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